This paper focuses on the GIS component of the author's Masters Thesis research conducted through the Department of Geography at the University of Regina. The quantitative study of the geomorphology of large regions has been neglected due to the large amounts of data that are necessary. Technological advancements particularly in data storage and processing now permit rigorous regional analysis. A GIS is well suited to this type of research and was applied as the primary tool to facilitate an assessment of the Geomorphic Sensitivity (GS) of the Palliser Triangle region of southwestern Saskatchewan and southeastern Alberta. Geomorphic Response Units (GRUs) have been proposed as the basic units of subdivision for the regions. The theory behind these units was developed through a synthesis of the literature and a practical application. GRUs have been mapped for a portion of the study and relatively ranked according to GS. Many challenges were experienced over the duration of this research project. Hardware limitation were of foremost concern during the early stages as the amount of data was soon greater than storage capabilities. Data availability also limited the project in terms of applying the optimum methodology. This research emphasized several problems with the newfound capabilities of formatting. Purchase agreements were made by administrative personal who possessed little knowledge of the data being sold or purchased with no guarantee of quality or completeness. The reality for regional geomorphic studies that utilize a GIS is a lack of digital data and/or a lack of high quality digital data. Within the next 5 years data of the quality and type needed for a truly rigorous regional geomorphic study will be available.